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Biological and Physicochemical Study of the Implantation of a Modified Polyester Vascular Prosthesis

Research and development

Authors:

• Niekraszewicz Antoni
  Poland, Łódź, Institute of Biopolymers and Chemical Fibres
• Kucharska Magdalena (j/w)
• Wiśniewska-Wrona Maria (j/w)
• Kardas Iwona (j/w)

Full text

Abstract: Results are presented of an investigation into the susceptibility to hydrolytic and enzymatic degradation of poly(DL-lactide-co-glycolide) copolymers of varied composition. Assessment of the degradation was based on two factors: measurement of the mass loss and estimation of the molecular mass by the GPC method. The examination made it possible to select copolymers for the temporary sealing of polyester vessel prostheses. The sealed vessel prostheses manifested full biocompatibility in the range of irritating action, systemic toxicity, haemolytic action, cytotoxicity and genotoxicity. The usefulness of the polymeric material applied was also confirmed by examination of the local reaction of implants in test animals. The impact of accelerated ageing and radiation sterilisation upon the physical-mechanical properties of the vessel prostheses was also studied. The studies enabled to prepare tentative technology guidelines for the sealing of artificial blood vessels with a biocompatible and resorbable synthetic copolymer – lactide/glycolide.

Tags: vessel prosthesis, poly(DL-lactide-co-glycolide), degradtion, sealing, biocompatibility, implantation..

Citation: Niekraszewicz A., Kucharska M., Wiśniewska-Wrona M., Kardas I.; Biological and Physicochemical Study of the Implantation of a Modified Polyester Vascular Prosthesis. FIBRES & TEXTILES in Eastern Europe 2010, Vol. 18, No. 6 (83) pp. 100-105.

Published on issue no 6 (83) / 2010, pages 100–105.

"Fibres & Textiles in Eastern Europe" is inserted on the "ISI Master Journal List" of the Institute for Scientific Information, Philadelphia, USA (for the year 2010 has an Impact Factor of 0.629) and is indexed in Research Alert, SCI Expanded (Sci Search and Web of Science), the Materials Science Citation Index, Current Contents/Engineering, Computing & Technology; as well as by the Textile Institute, Manchester, in the Information Service; and in Toga FIZ Technik; Rapra Technology Ltd.; Elsevier Geo Abstracts; Textiles Eastern Europe - World Textile Publications; Applied Mechanics Review; Chemical Abstracts Service; Referativny hurnal; and by the European Textile Network.

The content of "Fibres & Textiles in Eastern Europe" is available by free open access on the website http://www.fibtex.lodz.pl, starting from issue No 3/2002.